Anti-jagged canonical Notch ligand 2 antibodies are used for the immunodetection of the protein encoded by the JAG2 gene. In humans, the canonical protein has a reported length of 1238 amino acid residues and a mass of 133.4 kDa. Its subcellular localization is in the membrane. Alternative splicing is reported to yield 2 different isoforms for this protein. It is found to be expressed in the heart, placenta and skeletal muscle and to a lesser extent in the pancreas. It is noted to be involved in the differentiation of certain cell types. Post-translational modifications have been described, including glycosylation. The gene encoding this protein is implicated in Muscular dystrophy. Other names for this target antigen include LGMDR27, SER2, protein jagged-2, jagged 2, and HJ2. Gene orthologs have been identified in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species.