Anti-milk fat globule EGF and factor V/VIII domain containing antibodies are used for the immunodetection of the protein encoded by the MFGE8 gene. In humans, the canonical protein has a reported length of 387 amino acid residues and a mass of 43.1 kDa. Its subcellular localization is in the cytoplasmic vesicles, membrane, and is secreted. Alternative splicing is reported to yield 4 different isoforms for this protein. It is known to play an important role in the maintenance of intestinal epithelial homeostasis and the promotion of mucosal healing. Post-translational modifications have been described, including glycosylation. Other names for this target antigen include EDIL1, HMFG, HsT19888, MFGM, OAcGD3S, SED1, SPAG10, and BA46. Gene orthologs have been identified in the mouse, rat, bovine, frog, chimpanzee and chicken species.