Anti-SPG7 matrix AAA peptidase subunit, paraplegin antibodies are used for the immunodetection of the protein encoded by the SPG7 gene. In humans, the canonical protein has a reported length of 795 amino acid residues and a mass of 88.2 kDa. Its subcellular localization is in the mitochondria. Alternative splicing is reported to yield 2 different isoforms for this protein. It is ubiquitously expressed across many tissue types. A member of the AAA ATPase protein family; Peptidase M41 protein family, it is known to be involved with nervous system development and proteolysis. Post-translational modifications have been described, including protein cleavage. The gene encoding this protein is implicated in Spastic paraplegia. Other names for this target antigen include CMAR, PGN, SPG5C, paraplegin, SPG7, paraplegin matrix AAA peptidase subunit, and CAR. Gene orthologs have been identified in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species.