Anti-notch receptor 2 antibodies are used for the immunodetection of the protein encoded by the NOTCH2 gene. In humans, the canonical protein has a reported length of 2471 amino acid residues and a mass of 265.4 kDa. Its subcellular localization is in the cell membrane, nucleus, and cytoplasm. It is reported to be expressed in the brain, heart, kidney, lung, skeletal muscle and liver. A member of the NOTCH protein family, it is known to function as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Post-translational modifications have been described, including glycosylation, ubiquitination, protein cleavage and phosphorylation. The gene encoding this protein is implicated in Alagille syndrome. Other names for this target antigen include HJCYS, hN2, neurogenic locus notch homolog protein 2, Notch homolog 2, and AGS2. Gene orthologs have been identified in the mouse, rat, bovine, frog, chimpanzee and chicken species.