Anti-VRK serine/threonine kinase 1 antibodies are used for the immunodetection of the protein encoded by the VRK1 gene. In humans, the canonical protein has a reported length of 396 amino acid residues and a mass of 45.5 kDa. Its subcellular localization is in the nucleus and cytoplasm. It is widely expressed across many tissue types. A member of the CK1 Ser/Thr protein kinase protein family, it is known to be a serine/threonine kinase involved in cell cycle, nuclear condensation and transcription regulation. Post-translational modifications have been described, including phosphorylation. The gene encoding this protein is implicated in Pontocerebellar hypoplasia. Other names for this target antigen include PCH1A, serine/threonine-protein kinase VRK1, vaccinia related kinase 1, vaccinia virus B1R-related kinase 1, and PCH1. Gene orthologs have been identified in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species.