Anti-H1-2 antibodies are used in the immunodetection of the protein H1.2 linker histone, cluster member. In humans, the canonical protein has a reported length of 213 amino acid residues and a mass of 21.4 kDa. Its subcellular localization is in the nucleus and chromosomes. It is notably widely expressed in many tissue types. A member of the Histone H1/H5 protein family, H1-2 is known to be involved with the regulation of transcription. Post-translational modifications have been described, including phosphorylation. Synonyms for this target antigen include H1C, H1F2, H1s-1, HIST1H1C, histone H1.2, H1 histone family, member 2, histone 1, H1c, and H1.2. H1-2 gene orthologs have been reported in the mouse, rat, bovine and chimpanzee species.