Anti-RAG2 antibodies are used in the immunodetection of the protein recombination activating 2. In humans, the canonical protein has a reported length of 527 amino acid residues and a mass of 59.2 kDa. Its subcellular localization is in the nucleus. A member of the RAG2 protein family, RAG2 is an important component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. The RAG2 marker can be used to identify Committed Double Negative Thymocytes and Rearranging Double Negative Thymocytes.* Synonyms for this target antigen include V(D)J recombination-activating protein 2 and recombination activating gene 2. RAG2 gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. Some RAG2 antibodies may have been used in research and have associated citations. Western Blot is a widely used application for these antibodies. Immunofluorescence and Immunohistochemistry are also common applications.
*HuBMAP Human Reference Atlas v1.4