Anti-AD4 antibodies are used in antigen-specific immunodetection in biological samples. The target AD4 is a known alias name of the protein presenilin 2, encoded by the PSEN2 gene in humans. This 448-amino acid residue protein is a suspected catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). It is localized to the ER and Golgi of the cell and features cleaved and phosphorylated post-translational modifications. Other synonyms for AD4 include AD3L and CMD1V. Western Blot is a widely used application for the AD4 antibodies listed below. In addition, Immunohistochemistry is also a common application.