Anti-CYREN antibodies are used in the immunodetection of the protein cell cycle regulator of NHEJ. In humans, the canonical protein has a reported length of 157 amino acid residues and a mass of 16.8 kDa. Its subcellular localization is in the nucleus and cytoplasm. Up to 4 different isoforms have been reported for this protein. It is notably widely expressed in many tissue types. CYREN is a reported cell-cycle-specific regulator of classical non-homologous end joining (NHEJ) of DNA double-strand break (DSB) repair, which can act both as an activator or inhibitor of NHEJ, depending on the cell cycle phase. Synonyms for this target antigen include cell cycle regulator of non-homologous end joining and modulator of retrovirus infection homolog. CYREN gene orthologs have been reported in the mouse, rat, bovine, chimpanzee and chicken species. ELISA, Western Blot, and Immunohistochemistry are common applications for CYREN antibodies.