Anti-platelet factor 4 antibodies are used for the immunodetection of the protein encoded by the PF4 gene. In humans, the canonical protein has a reported length of 101 amino acid residues and a mass of 10.8 kDa. It is known to be a secreted protein. A member of the Intercrine alpha (chemokine CxC) protein family, it is known to be involved with GPCR signaling pathways and the cellular response to lipopolysaccharides.
The platelet factor 4 marker can be used to characterize Megakaryocytes (MK), Lung Megakaryocytes, and Platelets.* Other names for this target antigen include SCYB4, C-X-C motif chemokine 4, chemokine (C-X-C motif) ligand 4, iroplact, oncostatin-A, and CXCL4. Gene orthologs have been identified in the mouse, rat, bovine and chimpanzee species. A number of platelet factor 4 antibodies have been mentioned in research publications and have associated citations. Western Blot is a widely used application for these antibodies. ELISA and Immunohistochemistry are also common applications.
*HuBMAP Human Reference Atlas v1.4