Anti-MTHFS antibodies are used in the immunodetection of the protein methenyltetrahydrofolate synthetase. In humans, the canonical protein has a reported length of 203 amino acid residues and a mass of 23.3 kDa. Its subcellular localization is in the cytoplasm. Up to 2 different isoforms have been reported for this protein. It is notably widely expressed in many tissue types. A member of the 5-formyltetrahydrofolate cyclo-ligase protein family, MTHFS is known to be involved with metabolic processes. Synonyms for this target antigen include NEDMEHM, 5-formyltetrahydrofolate cyclo-ligase, 5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase), methenyl-THF synthetase, and HsT19268. MTHFS gene orthologs have been reported in the mouse, frog, zebrafish and chimpanzee species. Some MTHFS antibodies may have been used in research and have associated citations. Western Blot is a widely used application for these antibodies. ELISA and Immunohistochemistry are also common applications.