Anti-DExH-box helicase 34 antibodies are used in the immunodetection of the protein encoded by the DHX34 gene. In humans, the canonical protein has a reported length of 1143 amino acid residues and a mass of 128.1 kDa. It is reported to be expressed in whole blood, testis and spleen. A member of the DEAD box helicase protein family, it is a suspected ATP-binding RNA helicase required for nonsense-mediated decay (NMD) degradation of mRNA transcripts containing premature stop codons. Other names for this target antigen include HRH1, probable ATP-dependent RNA helicase DHX34, DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 34, DEAH (Asp-Glu-Ala-His) box polypeptide 34, and DDX34.