Anti-AKT1 substrate 1 antibodies are used for the immunodetection of the protein encoded by the AKT1S1 gene. In humans, the canonical protein has a reported length of 256 amino acid residues and a mass of 27.4 kDa. Its subcellular localization is in the cytoplasm. Alternative splicing is reported to yield 3 different isoforms for this protein. It is reported to be widely expressed with highest levels of expression in the liver and heart. It is noted to be involved in the regulation of apoptosis. Post-translational modifications have been described, including phosphorylation. Other names for this target antigen include 40 kDa proline-rich AKT substrate, AKT1 substrate 1 (proline rich), and proline-rich AKT1 substrate 1. Gene orthologs have been identified in the mouse, rat, bovine, frog, zebrafish and chimpanzee species. Over 580 citations in the literature describe the use of AKT1 substrate 1 antibodies in research. Western Blot is a widely used application for these antibodies. ELISA and Immunohistochemistry are also common applications.