Anti-TNFRSF21 antibodies are used in the immunodetection of the protein TNF receptor superfamily member 21. In humans, the canonical protein has a reported length of 655 amino acid residues and a mass of 71.8 kDa. Its subcellular localization is in the cell membrane. It is notably expressed in fetal spinal cord and in the brain neurons, with higher levels in the brain from Alzheimer disease patients. TNFRSF21 is reported to promote apoptosis, possibly via a pathway that involves the activation of NF-kappa-B. Post-translational modifications have been described, including glycosylation. Synonyms for this target antigen include CD358, DR6, tumor necrosis factor receptor superfamily member 21, TNFR-related death receptor 6, death receptor 6, and BM-018. TNFRSF21 gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. A number of TNFRSF21 antibodies have been mentioned in research publications and have associated citations. ELISA is a widely used application for these antibodies. In addition, Western Blot is also a common application.