Anti-SYK antibodies are used in the immunodetection of the protein spleen associated tyrosine kinase. In humans, the canonical protein has a reported length of 635 amino acid residues and a mass of 72.1 kDa. Its subcellular localization is in the cell membrane and cytoplasm. Up to 2 different isoforms have been reported for this protein. It is found to be widely expressed in hematopoietic cells. A member of the Tyr protein kinase protein family, SYK is a type of non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR).
The SYK marker can be used to identify Lympho-Myeloid Progenitor (Lmpp) Cells.* Synonyms for this target antigen include p72-Syk, tyrosine-protein kinase SYK, spleen tyrosine kinase, and IMD82. SYK gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. Over 1100 citations in the literature describe the use of SYK antibodies in research. Western Blot is a widely used application for these antibodies. ELISA and Immunohistochemistry are also common applications.
*HuBMAP Human Reference Atlas v1.4