Anti-NPC2 antibodies are used in the immunodetection of the protein NPC intracellular cholesterol transporter 2. In humans, the canonical protein has a reported length of 151 amino acid residues and a mass of 16.6 kDa. Its subcellular localization is in the ER, lysosomes, and is secreted. Up to 2 different isoforms have been reported for this protein. It is notably expressed in gallbladder bile. A member of the NPC2 protein family, NPC2 is known to be involved with cholesterol metabolism and homeostasis. Synonyms for this target antigen include HE1, Niemann-Pick disease type C2 protein, epididymal protein 1, epididymis secretory sperm binding protein, human epididymis-specific protein 1, and EDDM1. NPC2 gene orthologs have been reported in the mouse, rat, bovine, frog, chimpanzee and chicken species. A number of NPC2 antibodies have been mentioned in research publications and have associated citations. ELISA is a widely used application for these antibodies. Western Blot and Immunohistochemistry are also common applications.