Anti-IKBKB antibodies are used in the immunodetection of the protein inhibitor of nuclear factor kappa B kinase subunit beta. In humans, the canonical protein has a reported length of 756 amino acid residues and a mass of 86.6 kDa. Its subcellular localization is in the nucleus and cytoplasm. Up to 4 different isoforms have been reported for this protein. It is reported to be highly expressed in the heart, placenta, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis and peripheral blood. A member of the Ser/Thr protein kinase protein family, IKBKB is reported to be a serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Synonyms for this target antigen include IKK2, IKKB, IMD15, IMD15A, IMD15B, NFKBIKB, I-kappa-B kinase 2, and IKK-beta. Over 960 citations in the literature describe the use of IKBKB antibodies in research. Western Blot is a widely used application for these antibodies. ELISA, Immunofluorescence, and Immunohistochemistry are also common applications.