Anti-H2BC12 antibodies are used in the immunodetection of the protein H2B clustered histone 12. In humans, the canonical protein has a reported length of 126 amino acid residues and a mass of 13.9 kDa. Its subcellular localization is in the nucleus and chromosomes. It is notably widely expressed in many tissue types. A member of the Histone H2B protein family, H2BC12 is an important component of nucleosome. Post-translational modifications have been described, including glycosylation, ubiquitination and phosphorylation. Synonyms for this target antigen include H2B K, H2B histone family, member T, HIRA-interacting protein 1, histone 1, H2bk, histone cluster 1 H2B family member k, and histone H2B type 1-K. H2BC12 gene orthologs have been reported in the mouse, rat and chimpanzee species.