Anti-GCNA antibodies are used in the immunodetection of the protein germ cell nuclear acidic peptidase. In humans, the canonical protein has a reported length of 691 amino acid residues and a mass of 76.1 kDa. Its subcellular localization is in the nucleus. It is reported to be expressed in germ cells of the testis. A member of the Serine-aspartate repeat-containing protein (SDr) protein family, GCNA is believed to play a role in DNA-protein cross-links (DPCs) clearance through a SUMO-dependent recruitment to sites of DPCs, ensuring the genomic stability by protecting germ cells and early embryos from various sources of damage. The GCNA gene has been associated with the disease, Spermatogenic failure. Synonyms for this target antigen include acidic repeat containing, acidic repeat-containing protein, germ cell nuclear antigen, putative nuclear protein, and germ cell nuclear acidic protein. GCNA gene orthologs have been reported in the bovine, frog, chimpanzee and chicken species. Some GCNA antibodies may have been used in research and have associated citations. Western Blot is a widely used application for these antibodies. In addition, ELISA is also a common application.