Anti-COL14A1 antibodies are used in the immunodetection of the protein collagen type XIV alpha 1 chain. In humans, the canonical protein has a reported length of 1796 amino acid residues and a mass of 193.5 kDa. Its subcellular localization is in the extracellular matrix and is secreted. Up to 3 different isoforms have been reported for this protein. A member of the Fibril-associated collagens with interrupted helices (FACIT) protein family, COL14A1 is known to play an adhesive role by integrating collagen bundles.
The COL14A1 marker can be used to identify Type 2 Thymic Fibroblasts.* Synonyms for this target antigen include collagen alpha-1(XIV) chain, collagen, type XIV, alpha 1, undulin (fibronectin-tenascin-related), and UND. COL14A1 gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. A number of COL14A1 antibodies have been mentioned in research publications and have associated citations. Immunohistochemistry is a widely used application for these antibodies. ELISA, Western Blot, and Immunofluorescence are also common applications.
*HuBMAP Human Reference Atlas v1.4