Anti-CLEC11A antibodies are used in the immunodetection of the protein C-type lectin domain containing 11A. In humans, the canonical protein has a reported length of 323 amino acid residues and a mass of 35.7 kDa. Its subcellular localization is in the cytoplasm and is secreted. It is reported to be expressed in skeletal tissues including bone marrow, chondrocytes, primary ossification center-associated cells, the perichondrium and periosteum. CLEC11A is reported to promote osteogenesis by stimulating the differentiation of mesenchymal progenitors into mature osteoblasts. Post-translational modifications have been described, including O-glycosylation and sulfation. The CLEC11A marker can be used to identify Granulocyte-Macrophages Progenitor Cells (GMP).* Synonyms for this target antigen include LSLCL, P47, SCGF, C-type lectin domain family 11 member A, and CLECSF3. CLEC11A gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish and chimpanzee species.
*HuBMAP Human Reference Atlas v1.4