Anti-TNFSF11 antibodies are used in the immunodetection of the protein TNF superfamily member 11. In humans, the canonical protein has a reported length of 317 amino acid residues and a mass of 35.5 kDa. Its subcellular localization is in the cell membrane, cytoplasm, and is secreted. Up to 3 different isoforms have been reported for this protein. It is notably expressed in the tonsil, spleen, lymph node, and bone marrow. A member of the Tumor necrosis factor protein family, Tnfsf11 is a reported to be a cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Post-translational modifications have been described, including protein cleavage and glycosylation.
The TNFSF11 marker can be used to identify Lymph Node Marginal Reticular Cells, B Cells Zone Reticular Cells, and Medullary Reticular Cells.* Synonyms for this target antigen include ODF, OPGL, OPTB2, RANKL, TNLG6B, TRANCE, hRANKL2, and CD254. TNFSF11 gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species.
*HuBMAP Human Reference Atlas v1.4