Anti-Fumarate Hydratase antibodies are used for the immunodetection of the protein encoded by the FH gene. In humans, the canonical protein has a reported length of 510 amino acid residues and a mass of 54.6 kDa. Its subcellular localization is in the nucleus, mitochondria, and cytoplasm. It is reported to be expressed in red blood cells; underexpressed in red blood cells (cytoplasm) of patients with hereditary non-spherocytic hemolytic anemia of unknown etiology. A member of the Class-II fumarase/aspartase protein family, it is known to catalyze the reversible stereospecific interconversion of fumarate to L-malate. Other names for this target antigen include HLRCC, HsFH, LRCC, MCL, MCUL1, and FMRD. Gene orthologs have been identified in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. Over 90 citations in the literature describe the use of Fumarate Hydratase antibodies in research. Western Blot is a widely used application for these antibodies. ELISA, Immunofluorescence, and Immunohistochemistry are also common applications.