Anti-NR2E1 antibodies are used in the immunodetection of the protein nuclear receptor subfamily 2 group E member 1. In humans, the canonical protein has a reported length of 385 amino acid residues and a mass of 42.6 kDa. Its subcellular localization is in the nucleus. Alternative splicing is reported to yield 2 different isoforms for this protein. It is reported to have brain specific expression. A member of a the Nuclear hormone receptor protein family, NR2E1 is reported to be an orphan receptor that binds DNA as a monomer to hormone response elements (HRE) containing an extended core motif half-site sequence 5'-AAGGTCA-3' in which the 5' flanking nucleotides participate in determining receptor specificity (By similarity). Synonyms for this target antigen include TLX, XTLL, nuclear receptor TLX, protein tailless homolog, tailes-related receptor, tailless, and TLL.