Anti-TBX21 antibodies are used in the immunodetection of the protein T-box transcription factor 21. In humans, the canonical protein has a reported length of 535 amino acid residues and a mass of 58.3 kDa. Its subcellular localization is in the nucleus. It is reported to have t-cell specific expression. TBX21 is known to be involved with the regulation of transcription and the regulation of cell differentiation. Post-translational modifications have been described, including ubiquitination and phosphorylation.
The TBX21 marker can be used to identify TBet Low Liver NK Cells, Natural Killer (NK) Cells, and Pit Cells.* Synonyms for this target antigen include T-PET, T-bet, TBET, TBLYM, T-box transcription factor TBX21, T-box 21, T-box expressed in T cells, and IMD88. TBX21 gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. Over 1100 citations in the literature describe the use of TBX21 antibodies in research. Western Blot is a widely used application for these antibodies. In addition, Flow Cytometry is also a common application.
*HuBMAP Human Reference Atlas v1.4