Anti-family with sequence similarity 63 member B antibodies are used in antigen-specific immunodetection in biological samples. The target family with sequence similarity 63 member B is a known alias name of the protein MINDY lysine 48 deubiquitinase 2, encoded by the MINDY2 gene in humans. This 621-amino acid residue protein is a known hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins. It is reported to be widely expressed in many tissue types.