Anti-glucuronidase beta antibodies are used in the immunodetection of the protein encoded by the GUSB gene. In humans, the canonical protein has a reported length of 651 amino acid residues and a mass of 74.7 kDa. Its subcellular localization is in the lysosomes. Alternative splicing is reported to yield 3 different isoforms for this protein. A member of the Glycosyl hydrolase 2 protein family, it is known to play an important role in the degradation of dermatan and keratan sulfates. Post-translational modifications have been described, including glycosylation. Other names for this target antigen include MPS7, beta-glucuronidase, beta-D-glucuronidase, beta-G1, and BG.