Anti-CRB1 antibodies are used in the immunodetection of the protein crumbs cell polarity complex component 1. In humans, the canonical protein has a reported length of 1406 amino acid residues and a mass of 154.2 kDa. Its subcellular localization is in the cell membrane and is secreted. Up to 5 different isoforms have been reported for this protein. It is notably expressed in the retina. A member of the Crumbs protein family, CRB1 is reported to play a role in photoreceptor morphogenesis in the retina (By similarity). Post-translational modifications have been described, including glycosylation. The CRB1 gene has been associated with the disease, Retinitis pigmentosa. Synonyms for this target antigen include CRB1-B, CRB1-C, LCA8, RP12, protein crumbs homolog 1, and CRB1-A. CRB1 gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. Some CRB1 antibodies may have been used in research and have associated citations. ELISA, Western Blot, Immunofluorescence, and Immunohistochemistry are common applications for these antibodies.