Anti-PTPN11 antibodies are used in the immunodetection of the protein protein tyrosine phosphatase non-receptor type 11. In humans, the canonical protein has a reported length of 593 amino acid residues and a mass of 68 kDa. Its subcellular localization is in the nucleus and cytoplasm. Up to 3 different isoforms have been reported for this protein. It is found to be widely expressed, with highest levels in the heart, brain, and skeletal muscle. A member of the Protein-tyrosine phosphatase protein family, PTPN11 is known to act downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Synonyms for this target antigen include BPTP3 and CFC. PTPN11 gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. Over 370 citations in the literature describe the use of PTPN11 antibodies in research. Western Blot is a widely used application for these antibodies. ELISA, Immunofluorescence, and Immunohistochemistry are also common applications.