Anti-TNFRSF13B antibodies are used in the immunodetection of the protein TNF receptor superfamily member 13B. In humans, the canonical protein has a reported length of 293 amino acid residues and a mass of 31.8 kDa. Its subcellular localization is in the membrane. Up to 3 different isoforms have been reported for this protein. It is reported to be highly expressed in spleen, thymus, small intestine and peripheral blood leukocytes. TNFRSF13B is a known receptor for TNFSF13/APRIL and TNFSF13B/TALL1/BAFF/BLYS that binds both ligands with similar high affinity. Post-translational modifications have been described, including glycosylation.
The TNFRSF13B marker can be used to identify Mantle Zone B Cells, Unswitched Memory B Cells, and Class Switched Memory B Cells.* Synonyms for this target antigen include CVID, CVID2, IGAD2, RYZN, TACI, TNFRSF14B, tumor necrosis factor receptor superfamily member 13B, and CD267. TNFRSF13B gene orthologs have been reported in the mouse, rat, bovine, zebrafish, chimpanzee and chicken species.
*HuBMAP Human Reference Atlas v1.4