Anti-ID2 antibodies are used in the immunodetection of the protein inhibitor of DNA binding 2. In humans, the canonical protein has a reported length of 134 amino acid residues and a mass of 14.9 kDa. Its subcellular localization is in the nucleus and cytoplasm. It is reported to be highly expressed in early fetal tissues, including those of the central nervous system. ID2 is known to be involved with the differentiation of certain cell types.
The ID2 marker can be used to identify T Helper 1 Cells, T Helper 2 Cells, T Helper 17 Cells, Natural Killer Cells, and Gamma-Delta T Cells.* Synonyms for this target antigen include ID2A, ID2H, bHLHb26, DNA-binding protein inhibitor ID-2, DNA-binding protein inhibitor ID2, and GIG8. ID2 gene orthologs have been reported in the mouse, rat, bovine, frog, chimpanzee and chicken species. A number of ID2 antibodies have been mentioned in research publications and have associated citations. Western Blot is a widely used application for these antibodies. Immunofluorescence and Immunohistochemistry are also common applications.
*HuBMAP Human Reference Atlas v1.4