Anti-CCR5 antibodies are used in the immunodetection of the protein C-C motif chemokine receptor 5. In humans, the canonical protein has a reported length of 352 amino acid residues and a mass of 40.5 kDa. Its subcellular localization is in the cell membrane. It is reported to be highly expressed in spleen, thymus, in the myeloid cell line THP-1, in the promyeloblastic cell line KG-1a and on CD4+ and CD8+ T-cells. A member of the G-protein coupled receptor 1 protein family, CCR5 is a known receptor for a number of inflammatory CC-chemokines including CCL3/MIP-1-alpha, CCL4/MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. CCR5 is also used as a cellular marker for characterizing NK T cells and granulocytes. Synonyms for this target antigen include CCCKR5, CD195, CKR-5, CKR5, CMKBR5, IDDM22, C-C chemokine receptor type 5, and CC-CKR-5. CCR5 gene orthologs have been reported in the mouse, rat, chimpanzee and chicken species.