Anti-tubulin beta class I antibodies are used for the immunodetection of the protein encoded by the TUBB gene. In humans, the canonical protein has a reported length of 444 amino acid residues and a mass of 49.7 kDa. Its subcellular localization is in the cytoplasm. It is widely expressed across many tissue types. A member of the Tubulin protein family, it is known to be involved with cell division and cytoskeleton organization. Post-translational modifications have been described, including phosphorylation. Other names for this target antigen include beta Ib tubulin, epididymis secretory sperm binding protein, tubulin beta-1 chain, tubulin beta-5 chain, tubulin, beta polypeptide, and tubulin beta chain. Gene orthologs have been identified in the mouse, rat, bovine, frog and chimpanzee species. Over 5000 citations in the literature describe the use of tubulin beta class I antibodies in research. Western Blot is a widely used application for these antibodies. Immunocytochemistry, Immunofluorescence, and Immunohistochemistry are also common applications.