Anti-IL2RG antibodies are used in the immunodetection of the protein interleukin 2 receptor subunit gamma. In humans, the canonical protein has a reported length of 369 amino acid residues and a mass of 42.3 kDa. Its subcellular localization is in the cell membrane. Up to 2 different isoforms have been reported for this protein. It is notably expressed in the stomach, spleen, rectum, gallbladder, and colon. A member of the Type I cytokine receptor protein family, IL2RG is known to be involved with cytokine-mediated signaling pathways and immune response pathways. Post-translational modifications have been described, including glycosylation. The IL2RG marker can be used to identify Lympho-Myeloid Progenitor (Lmpp) Cells.* Synonyms for this target antigen include CIDX, IMD4, P64, SCIDX, SCIDX1, cytokine receptor common subunit gamma, CD132 antigen, and CD132. IL2RG gene orthologs have been reported in the mouse, rat, bovine, frog, chimpanzee and chicken species.
*HuBMAP Human Reference Atlas v1.4