Anti-COL1A2 antibodies are used in the immunodetection of the protein collagen type I alpha 2 chain. In humans, the canonical protein has a reported length of 1366 amino acid residues and a mass of 129.3 kDa. Its subcellular localization is in the extracellular matrix and is secreted. It is notably widely expressed in many tissue types. A member of the Fibrillar collagen protein family, COL1A2 is known to be involved with blood vessel development and extracellular matrix organization. Post-translational modifications have been described, including glycosylation.
The COL1A2 marker can be used to identify Brain Fibroblast Non-Neuronal Cells, Fibroblasts, Bronchial Smooth Muscle Cells, Lung Perichondrial Fibroblasts, and Tracheobronchial Chondrocytes.* Synonyms for this target antigen include EDSCV, OI4, collagen alpha-2(I) chain, alpha 2 type I procollagen, alpha 2(I) procollagen, and EDSARTH2. COL1A2 gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. Over 890 citations in the literature describe the use of COL1A2 antibodies in research. Western Blot is a widely used application for these antibodies. ELISA, Immunofluorescence, and Immunohistochemistry are also common applications.
*HuBMAP Human Reference Atlas v1.4