Anti-chymase 1 antibodies are used for the immunodetection of the protein encoded by the CMA1 gene. In humans, the canonical protein has a reported length of 247 amino acid residues and a mass of 27.3 kDa. Its subcellular localization is in the cytoplasm and is secreted. Alternative splicing is reported to yield 2 different isoforms for this protein. A member of the Peptidase S1 protein family, it is known to be involved with carbohydrate metabolism and homeostasis and the regulation of angiogenesis. Post-translational modifications have been described, including glycosylation.
The chymase 1 marker can be used to characterize Connective Tissue Type Mast Cells.* Other names for this target antigen include MCT1, chymase, alpha-chymase, chymase 1 preproprotein transcript E, chymase 1 preproprotein transcript I, and CYH. Gene orthologs have been identified in the mouse and chimpanzee species. Over 60 citations in the literature describe the use of chymase 1 antibodies in research. Western Blot is a widely used application for these antibodies. ELISA and Immunohistochemistry are also common applications.
*HuBMAP Human Reference Atlas v1.4