Anti-chitinase 3 like 2 antibodies are used for the immunodetection of the protein encoded by the CHI3L2 gene. In humans, the canonical protein has a reported length of 390 amino acid residues and a mass of 43.5 kDa. It is known to be a secreted protein. Alternative splicing is reported to yield 3 different isoforms for this protein. It is reported to be highly expressed in chondrocytes, followed by synoviocytes, lung and heart. A member of the Glycosyl hydrolase 18 protein family, it is a reported lectin that binds chitooligosaccharides and other glycans with high affinity, but not heparin. Post-translational modifications have been described, including glycosylation.
The chitinase 3 like 2 marker can be used to characterize Mature CD8 Single-Positive Thymocytes.* Other names for this target antigen include YKL-39, YKL39, chitinase-3-like protein 2, chondrocyte protein 39, and CHIL2. Gene orthologs have been identified in the mouse, rat, bovine and chimpanzee species. A number of chitinase 3 like 2 antibodies have been mentioned in research publications and have associated citations. ELISA, Western Blot, and Immunohistochemistry are common applications for these antibodies.
*HuBMAP Human Reference Atlas v1.4