Anti-sarcoglycan epsilon antibodies are used in the immunodetection of the protein encoded by the SGCE gene. In humans, the canonical protein has a reported length of 437 amino acid residues and a mass of 49.9 kDa. Its subcellular localization is in the cell membrane, golgi, and cytoplasm. Alternative splicing is reported to yield 3 different isoforms for this protein. It is ubiquitously expressed across many tissue types. A member of the Sarcoglycan alpha/epsilon protein family, it is a known component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix. Post-translational modifications have been described, including N-glycosylation, ubiquitination. Other names for this target antigen include DYT11 and ESG.