Anti-APBB1IP antibodies are used in the immunodetection of the protein amyloid beta precursor protein binding family B member 1 interacting protein. In humans, the canonical protein has a reported length of 666 amino acid residues and a mass of 73.2 kDa. Its subcellular localization is in the cell membrane and cytoplasm. Up to 2 different isoforms have been reported for this protein. It is reported to be widely expressed with high expression in thymus, spleen, lymph node, bone marrow and peripheral leukocytes. A member of the MRL protein family, APBB1IP is suggested to function in the signal transduction from Ras activation to actin cytoskeletal remodeling.
The APBB1IP marker can be used to identify Brain Microglia.* Synonyms for this target antigen include PREL1, RARP1, RIAM, amyloid beta A4 precursor protein-binding family B member 1-interacting protein, APBB1-interacting protein 1, and INAG1. APBB1IP gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species.
*HuBMAP Human Reference Atlas v1.4