Anti-phosphodiesterase 4A antibodies are used in the immunodetection of the protein encoded by the PDE4A gene. In humans, the canonical protein has a reported length of 886 amino acid residues and a mass of 98.1 kDa. Its subcellular localization is in the membrane and cytoplasm. Alternative splicing is reported to yield 7 different isoforms for this protein. A member of the Cyclic nucleotide phosphodiesterase protein family, it is reported to hydrolyze the second messenger 3',5'-cyclic AMP (cAMP), which is a key regulator of many important physiological processes. Post-translational modifications have been described, including protein cleavage and phosphorylation. Other names for this target antigen include PDE4, PDE46, cAMP-specific 3',5'-cyclic phosphodiesterase 4A, phosphodiesterase 4A, cAMP-specific (dunce, phosphodiesterase E2 dunce homolog, Drosophila, and DPDE2.