Anti-LAT2 antibodies are used in the immunodetection of the protein linker for activation of T cells family member 2. In humans, the canonical protein has a reported length of 243 amino acid residues and a mass of 26.6 kDa. Its subcellular localization is in the cell membrane. Up to 2 different isoforms have been reported for this protein. It is reported to be highly expressed in spleen, peripheral blood lymphocytes, and germinal centers of lymph nodes. LAT2 is known to be involved in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Post-translational modifications have been described, including ubiquitination and phosphorylation. The LAT2 marker can be used to identify Common Lymphoid Progenitors (CLP).* Synonyms for this target antigen include LAB, NTAL, WBSCR15, WBSCR5, WSCR5, and HSPC046. LAT2 gene orthologs have been reported in the mouse, rat, bovine, chimpanzee and chicken species.
*HuBMAP Human Reference Atlas v1.4