Anti-SHB antibodies are used in the immunodetection of the protein SH2 domain containing adaptor protein B. In humans, the canonical protein has a reported length of 509 amino acid residues and a mass of 55 kDa. Its subcellular localization is in the cell membrane and cytoplasm. Up to 2 different isoforms have been reported for this protein. It is widely expressed across many tissue types. SHB is reported to be an adapter protein, which regulates several signal transduction cascades by linking activated receptors to downstream signaling components. Synonyms for this target antigen include SH2 domain-containing adapter protein B, SHB (Src homology 2 domain containing) adaptor protein B, SHB adaptor protein (a Src homology 2 protein), and bA3J10.2. SHB gene orthologs have been reported in the mouse, rat, bovine, frog, chimpanzee and chicken species. Some SHB antibodies may have been used in research and have associated citations. Western Blot is a widely used application for these antibodies. In addition, ELISA is also a common application.