Anti-CACNA1A antibodies are used in the immunodetection of the protein calcium voltage-gated channel subunit alpha1 A. In humans, the canonical protein has a reported length of 2506 amino acid residues and a mass of 282.6 kDa. Its subcellular localization is in the cell membrane. Up to 6 different isoforms have been reported for this protein. It is notably expressed in the liver, duodenum, and cerebellum. A member of the Calcium channel alpha-1 subunit (TC 1.A.1.11) protein family, CACNA1A is known to be involved with chemical synaptic transmission and the regulation of intracellular calcium. Post-translational modifications have been described, including glycosylation. The CACNA1A gene has been associated with the disease, Spinocerebellar ataxia. Synonyms for this target antigen include BI, CACNL1A4, CAV2.1, DEE42, EA2, EIEE42, FHM, and APCA. CACNA1A gene orthologs have been reported in the mouse, rat, bovine, frog and chimpanzee species.