Anti-CLEC7A antibodies are used in the immunodetection of the protein C-type lectin domain containing 7A. In humans, the canonical protein has a reported length of 247 amino acid residues and a mass of 27.6 kDa. Its subcellular localization is in the cell membrane and cytoplasm. Up to 1 different isoforms have been reported for this protein. It is reported to be highly expressed in peripheral blood leukocytes and dendritic cells. CLEC7A is a reported lectin that functions as pattern recognizing receptor (PRR) specific for beta-1,3-linked and beta-1,6-linked glucans, which constitute cell wall constituents from pathogenic bacteria and fungi.
The CLEC7A marker can be used to identify Classical Inflammatory Monocytes, Non-Classical Or Patrolling Monocytes, Neutrophils, Basophils, and CDC1 CD141+ Myeloid Dendritic Cells.* Synonyms for this target antigen include C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 12, C-type lectin superfamily member 12, DC-associated C-type lectin 1, and C-type lectin domain family 7 member A. Over 250 citations in the literature describe the use of CLEC7A antibodies in research. These antibodies are most commonly used in Flow Cytometry experiments, among other applications.
*HuBMAP Human Reference Atlas v1.4