Anti-OLR1 antibodies are used in the immunodetection of the protein oxidized low density lipoprotein receptor 1. In humans, the canonical protein has a reported length of 273 amino acid residues and a mass of 31 kDa. Its subcellular localization is in the cell membrane and is secreted. Up to 3 different isoforms have been reported for this protein. It is notably expressed at high level in endothelial cells and vascular-rich organs such as placenta, lung, liver and brain, aortic intima, bone marrow, spinal cord and substantia nigra. OLR1 is a known receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells.
The OLR1 marker can be used to identify Brain Microglia.* Synonyms for this target antigen include LOX1, LOXIN, SCARE1, SLOX1, C-type lectin domain family 8 member A, and CLEC8A. OLR1 gene orthologs have been reported in the mouse, rat, bovine and chimpanzee species. Over 170 citations in the literature describe the use of OLR1 antibodies in research. ELISA and Western Blot are common applications for these antibodies.
*HuBMAP Human Reference Atlas v1.4