Anti-COL15A1 antibodies are used in the immunodetection of the protein collagen type XV alpha 1 chain. In humans, the canonical protein has a reported length of 1388 amino acid residues and a mass of 141.7 kDa. Its subcellular localization is in the extracellular matrix and is secreted. It is notably expressed in fibroblasts and urine. A member of the Multiplexin collagen protein family, COL15A1 is reported to be a structural protein that stabilizes microvessels and muscle cells, both in heart and in skeletal muscle.
The COL15A1 marker can be used to identify Brain Fibroblast Non-Neuronal Cells and Gray Matter Chandelier Neurons.* Synonyms for this target antigen include collagen XV, alpha-1 polypeptide, collagen type XV proteoglycan, collagen, type XV, alpha 1, endostatin-XV, restin, and collagen alpha-1(XV) chain. COL15A1 gene orthologs have been reported in the mouse, rat, bovine and chimpanzee species. A number of COL15A1 antibodies have been mentioned in research publications and have associated citations. Western Blot is a widely used application for these antibodies. In addition, Immunofluorescence is also a common application.
*HuBMAP Human Reference Atlas v1.4