Anti-5'-nucleotidase ecto Antibody Products

Anti-5'-nucleotidase ecto antibodies are used for the immunodetection of the protein encoded by the NT5E gene. In humans, the canonical protein has a reported length of 574 amino acid residues and a mass of 63.4 kDa. Its subcellular localization is in the cell membrane. Alternative splicing is reported to yield 2 different isoforms for this protein. A member of the 5'-nucleotidase protein family, it is known to catalyze the hydrolysis of nucleotide monophosphates, releasing inorganic phosphate and the corresponding nucleoside, with AMP being the preferred substrate. Post-translational modifications have been described, including glycosylation.

The 5'-nucleotidase ecto marker can be used to characterize Lymphatic Vessel Endothelial Cells, Subcapsular Sinus Ceiling Lymphatic Endothelial Cells, Trabecula Lymphatic Endothelial Cells, Medulla Ceiling Lymphatic Endothelial Cells, and Wharton's Jelly Mesenchymal Stromal Cells.* Other names for this target antigen include CD73, E5NT, NT, NT5, NTE, eN, eNT, and CALJA. Gene orthologs have been identified in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. Over 960 citations in the literature describe the use of 5'-nucleotidase ecto antibodies in research. Flow Cytometry, Western Blot, and Immunohistochemistry are common applications for these antibodies.