Anti-CXCL13 antibodies are used in the immunodetection of the protein C-X-C motif chemokine ligand 13. In humans, the canonical protein has a reported length of 109 amino acid residues and a mass of 12.7 kDa. It has been described to be a secreted protein. It is reported to be highly expressed in the liver, followed by spleen, lymph node, appendix and stomach. A member of the Intercrine alpha (chemokine CxC) protein family, CXCL13 is known to be involved with GTPase activation and receptor-mediated signaling pathways. The CXCL13 marker can be used to identify Lymph Node Marginal Reticular Cells, Follicular Dendritic Cells, Follicular Dendritic Cells (FDC), and Fibroblastic Reticular Cells (FRC).* Synonyms for this target antigen include ANGIE2, BCA-1, BCA1, BLC, BLR1L, SCYB13, C-X-C motif chemokine 13, and ANGIE. CXCL13 gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species.
*HuBMAP Human Reference Atlas v1.4