Anti-RRM2B antibodies are used in the immunodetection of the protein ribonucleotide reductase regulatory TP53 inducible subunit M2B. In humans, the canonical protein has a reported length of 351 amino acid residues and a mass of 40.7 kDa. Its subcellular localization is in the nucleus and cytoplasm. Up to 6 different isoforms have been reported for this protein. It is found to be widely expressed at a high level in skeletal muscle and at a weak level in thymus. A member of the Ribonucleoside diphosphate reductase small chain protein family, RRM2B is known to play a pivotal role in cell survival by repairing damaged DNA in a p53/TP53-dependent manner. Synonyms for this target antigen include MTDPS8B, P53R2, RCDFRD, ribonucleoside-diphosphate reductase subunit M2 B, and MTDPS8A. RRM2B gene orthologs have been reported in the mouse, rat, bovine, frog, chimpanzee and chicken species. A number of RRM2B antibodies have been mentioned in research publications and have associated citations. Western Blot is a widely used application for these antibodies. ELISA, Immunofluorescence, and Immunohistochemistry are also common applications.