Anti-TNFRSF17 antibodies are used in the immunodetection of the protein TNF receptor superfamily member 17. In humans, the canonical protein has a reported length of 184 amino acid residues and a mass of 20.2 kDa. Its subcellular localization is in the cell membrane. Up to 2 different isoforms have been reported for this protein. It is reported to be expressed in mature B-cells, but not in T-cells or monocytes. TNFRSF17 is a known receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL.
The TNFRSF17 marker can be used to identify Plasma Cells.* Synonyms for this target antigen include BCMA, CD269, TNFRSF13A, tumor necrosis factor receptor superfamily member 17, B cell maturation antigen, and BCM. TNFRSF17 gene orthologs have been reported in the mouse, rat, bovine, frog and chimpanzee species. Over 140 citations in the literature describe the use of TNFRSF17 antibodies in research. ELISA is a widely used application for these antibodies. In addition, Flow Cytometry is also a common application.
*HuBMAP Human Reference Atlas v1.4